{"id":9212,"date":"2026-04-17T10:25:13","date_gmt":"2026-04-17T08:25:13","guid":{"rendered":"https:\/\/antaresvisiongroup.com\/lifescience\/?page_id=9212"},"modified":"2026-04-17T10:25:16","modified_gmt":"2026-04-17T08:25:16","slug":"ampoule-inspection-in-pharmaceutical-manufacturing","status":"publish","type":"page","link":"https:\/\/antaresvisiongroup.com\/lifescience\/ampoule-inspection-in-pharmaceutical-manufacturing\/","title":{"rendered":"Ampoule Inspection in Pharmaceutical Manufacturing"},"content":{"rendered":"\n<div class=\"kbreadcrumb\" id=\"k_year\">\n    <div class=\"pure-container\">\n        <div class=\"pure-g\">\n            <div class=\"pure-u-1-1\">\n                <div class=\"breadcrumbs\"><a href=\"https:\/\/antaresvisiongroup.com\/lifescience\">Home<\/a> | <\/div>            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<style>\n\n    .kbreadcrumb{max-width: 1330px; margin-right: auto; margin-left: auto; font-size: 14px; color: #222222; padding-top: 15px; padding-bottom: 15px;\n        font-family: 'Exo', sans-serif;}\n    .kbreadcrumb a{color: inherit; 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Glass ampoules are widely used for sterile injectable medications because they provide an airtight hermetic seal that protects sensitive pharmaceutical formulations. However, the integrity of these containers must be carefully verified before products are released to the market.<\/p>\n\n\n\n<p>A modern <strong>ampoule inspection machine<\/strong> allows pharmaceutical manufacturers to provide <strong>particles inspection (visible particles) and cosmetic inspection (glass defects, improper sealing, opc or ring defects)<\/strong> &nbsp;and container integrity issues that may compromise the quality of injectable drugs. By combining advanced imaging technologies with automated handling systems, inspection equipment ensures that every ampoule meets strict pharmaceutical quality standards.<\/p>\n\n\n\n<p>Today, pharmaceutical production lines rely heavily on automated inspection systems to support regulatory compliance and protect patient safety. Technologies such as <strong>automatic ampoule inspection machine CCIT<\/strong> systems&nbsp; <strong>automatic visual inspection ampoules or combinate machines which are including both system <\/strong>&nbsp;platforms enable reliable high-speed inspection. of thousands of units per hour.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>High-Performance Ampoules Inspection Machines<\/strong><\/h2>\n\n\n\n<p>We provide a comprehensive range of ampoules inspection systems designed for various production speeds and container types.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>VRI Series: High-Speed Precision<\/strong><\/h3>\n\n\n\n<p>The VRI Inspection Machines represent the pinnacle of automated ampoules inspection technology, specifically engineered for high-output environments<strong>. With specific features such as the top handling system.<\/strong><\/p>\n\n\n\n<p>The VRI solution is designed for high-speed, high-performance inspection of ampoules, handling up to 400 pieces per minute. This advanced system <strong>can<\/strong> integrates Automatic Visual Inspection (AVI) with Container Closure Integrity Testing (CCIT) using high-voltage <strong>leak detection<\/strong> technology or vacuum decay, depending by product features. It can inspect the entire surface of each ampoules, ensuring comprehensive quality control.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>VRI VI: A dedicated ampoules <strong>visual inspection machine<\/strong> capable of reaching production speeds up to 400 ppm.<\/li>\n\n\n\n<li>VRI COMBINED:&nbsp;A multifunctional platform that integrates <strong>Visual Inspection &amp; High Voltage Leak Detection<\/strong> for total integrity testing, with speeds up to 400 ppm.<\/li>\n\n\n\n<li>VRI with Serialization: The ultimate inspection machine that <strong>combines visual inspection ampoules<\/strong> with <strong>primary packaging serialization<\/strong> to ensure full traceability, operating up to 400 ppm.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Convel Tech Series: Versatile &amp; Reliable<\/strong><\/h3>\n\n\n\n<p>Our Convel Tech inspection machine offers flexible ampoules inspection options adaptable to diverse line configurations. With traditional handling system, the&nbsp;Convel Tech&nbsp;machines offer reliable inspection of ampoules at speeds up to 400 pieces per minute.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Automatic Visual Inspection and (Convel Tech CM, C2, C3): These systems provide wide-range visual inspection of vials,&nbsp;from compact models at up to 200 ppm to high-capacity versions reaching up to 350 ppm.<\/li>\n\n\n\n<li>Integrated solutions (Convel tech CL and CT) are dedicated to those customers which are looking for a single integrated solution which matches a Visual inspection technology together with the High Voltage Leak Detection Container Closing Inspection Technology<\/li>\n\n\n\n<li>Leak Detection (Convel Tech TS, TC):&nbsp;Specialised vial inspection units focused on Automatic High Voltage Leak Detection to identify micro-cracks or pinholes, ranging from up to 200 ppm to up to 400 ppm.<\/li>\n<\/ul>\n\n\n\n<p><a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>Semi Automatic Ampoule Inspection Machine Solution<\/strong><\/strong><\/h3>\n\n\n\n<p>For slightly smaller-scale operations, the <a href=\"https:\/\/antaresvisiongroup.com\/lifescience\/products\/cy-convel-tech\/\">CY Convel Tech<\/a> offers reliable inspection of pre-filled syringes at speeds up to 200 pieces per minute. This solution combines Automatic Visual Inspection with high-voltage leak detection, featuring patented technology that excels in identifying microcracks or pinholes in syringe containers, ensuring sterility and safety<\/p>\n\n\n\n<p>Although fully automated systems are widely used in large production facilities, some manufacturers still rely on a semi automatic ampoule inspection machine for specific applications.<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<p>Semi-automatic equipment combines mechanical handling with manual inspection performed by trained operators. This approach is often used for:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>small production batches<\/li>\n\n\n\n<li>clinical trial manufacturing<\/li>\n\n\n\n<li>specialized injectable formulations<\/li>\n\n\n\n<li>lower-volume pharmaceutical production<a id=\"_msocom_1\"><\/a><\/li>\n<\/ul>\n\n\n\n<p>In these cases, the machine rotates and positions the ampoule while the operator visually inspects the container for particles or defects.<\/p>\n\n\n\n<p>While semi-automatic systems offer greater flexibility, they typically provide lower inspection speeds compared to a fully automatic ampoule inspection machine.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>Laboratory Equipment<\/strong><\/strong><\/h3>\n\n\n\n<p>Easy Series laboratory equipment enables operator-performed manual ampoule analysis and accommodates containers of different sizes. The systems perform inspections using visual inspection, headspace analysis, high-voltage leak detection, and vacuum decay testing.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\">Products and Containers Inspected<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Containers:&nbsp;Small-volume glass containers (vials and ampoules) and small-to-medium-volume formats (up to 100ml).<\/li>\n\n\n\n<li>Product Types:&nbsp;Liquid products in glass, freeze-dried (lyophilised) products, water-based and oil-based solutions, suspensions, emulsions, and powders.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">The Importance of Ampoules Inspection for Injectable Drugs<\/h2>\n\n\n\n<p>The process of ampoules inspection plays an essential role in pharmaceutical quality assurance. Injectable medications are administered directly into the human body, which means even small contaminants or structural defects can represent serious safety risks.<\/p>\n\n\n\n<p><strong>Ampoule inspection machines typically verify the following parameters:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>visible particulate contamination<\/li>\n\n\n\n<li>glass cosmetic defects<\/li>\n\n\n\n<li>ampoule tip integrity<\/li>\n\n\n\n<li>container closure integrity<\/li>\n\n\n\n<li>fill level accuracy<\/li>\n\n\n\n<li>presence of cracks or pinholes in the glass<\/li>\n\n\n\n<li>Structural quality of the ampoule body<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Inspection Method<\/strong><\/td><td><strong>Purpose<\/strong><\/td><\/tr><tr><td>Visual inspection<\/td><td>Detect visible particles and cosmetic defects<\/td><\/tr><tr><td>High voltage leak detection<\/td><td>Verify container closure integrity<\/td><\/tr><tr><td>Headspace analysis<\/td><td>Detect oxygen or gas anomalies<\/td><\/tr><tr><td>Vacuum decay<\/td><td>Identify container leaks<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\">Ampoule Visual Inspection Machine Technology<\/h2>\n\n\n\n<p>An ampoule visual inspection machine is specifically designed to evaluate transparent pharmaceutical containers under controlled lighting and imaging conditions. The machine spin each ampoule during inspection so that cameras can capture multiple angles of the container and the liquid solution inside.<\/p>\n\n\n\n<p>This controlled movement allows inspection systems to detect defects that may not be visible with static observation.<\/p>\n\n\n\n<p><strong>Modern systems combine several advanced technologies:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>high-resolution industrial cameras<\/li>\n\n\n\n<li>optical sensors<\/li>\n\n\n\n<li>automated container rotation<\/li>\n\n\n\n<li>controlled illumination environments<\/li>\n\n\n\n<li>image processing software<\/li>\n<\/ul>\n\n\n\n<p>These features enable reliable detection of contaminants and glass defects while maintaining high throughput speeds required for pharmaceutical production.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Automatic Ampoule Inspection Machine Systems \u2013 How it works<\/strong><\/h2>\n\n\n\n<p>An automatic ampoule inspection machine performs high-speed inspection with minimal human intervention. These systems are designed to operate continuously within pharmaceutical production lines and can inspect thousands of containers per hour.<\/p>\n\n\n\n<p><strong>The automated inspection process typically includes the following steps:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Container Feeding<\/strong> \u2013 ampoules are transferred from the filling line into the inspection machine.<\/li>\n\n\n\n<li><strong>Container Rotation<\/strong> \u2013 the ampoule is rotated to suspend any particles within the liquid formulation.<\/li>\n\n\n\n<li><strong>Imaging and Detection<\/strong> \u2013 high-speed cameras analyze the container for particles, cosmetic defects, and glass anomalies.<\/li>\n\n\n\n<li><strong>Automatic Rejection<\/strong> \u2013 defective units are automatically removed from the production flow.<\/li>\n<\/ol>\n\n\n\n<p>This automated process significantly reduces human error and ensures consistent inspection performance.<\/p>\n\n\n\n<p>Many pharmaceutical companies rely on advanced <strong>automatic visual inspection ampoules<\/strong> systems to maintain quality standards while supporting high-volume manufacturing.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Technology used for Ampoules Inspection<\/strong><\/h2>\n\n\n\n<p>These machines are designed to deliver high-accuracy inspection for pharmaceutical applications where product safety and regulatory compliance are critical. Advanced optical systems and precision mechanics allow these machines to identify even small defects in glass ampoules.<\/p>\n\n\n\n<p>Technologies used in an <strong>ampoule inspection machine<\/strong> typically include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>multi-camera inspection systems<\/li>\n\n\n\n<li>advanced lighting configurations<\/li>\n\n\n\n<li>High voltage leak detection<\/li>\n\n\n\n<li><strong>Vacuum decay\/pressure decay<\/strong><\/li>\n\n\n\n<li>Head space gas analysis<\/li>\n\n\n\n<li>automated container handling mechanisms<\/li>\n\n\n\n<li>high-speed defect detection algorithms<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Regulatory Requirements for Ampoules Inspection<\/strong><\/h2>\n\n\n\n<p>Authorities and regulatory standards typically require inspection processes capable of identifying visible particulate matter and container defects.<\/p>\n\n\n\n<p>A properly implemented ampoules inspection process helps pharmaceutical companies comply with key regulatory frameworks such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Good Manufacturing Practices (GMP)<\/li>\n\n\n\n<li>international pharmacopeial standards<\/li>\n\n\n\n<li>regulatory guidelines for parenteral products<\/li>\n<\/ul>\n\n\n\n<p>Automated inspection systems provide documented, repeatable inspection results that support quality assurance and regulatory audits.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<!-- F.A.Q. -->\n<div class=\"kfaq\">\n    <div class=\"pure-container-fluid\">\n        <div class=\"pure-container\">\n            <div class=\"pure-g\">\n                <div class=\"pure-u-1-1\">\n                                            <h2 class=\"kfaq__title\">Frequently Asked Questions (FAQ)<\/h2>\n                                    <\/div>\n\n                <div class=\"pure-u-1-1 kfaq__colLeft\">\n                    <div class=\"kfaq__colLeftContDesc tabs__container\">\n                        \n                            <div class=\"tab__single\">\n                                <input type=\"checkbox\" id=\"chck1\">\n                                <label class=\"tab__singleTitle\" for=\"chck1\"><h3>What is ampoule inspection?<\/h3><\/label>\n                                <div class=\"tab__singleContent\">\n                                    <div class=\"tab__singleContentInt\">\n                                        <p>Ampoule inspection is a pharmaceutical quality control process used to verify that glass ampoules containing injectable drugs are free from visible particles and structural defects.<\/p>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                            \n                            <div class=\"tab__single\">\n                                <input type=\"checkbox\" id=\"chck2\">\n                                <label class=\"tab__singleTitle\" for=\"chck2\"><h3>When Is an Ampoule Inspection Machine Used?<\/h3><\/label>\n                                <div class=\"tab__singleContent\">\n                                    <div class=\"tab__singleContentInt\">\n                                        <p>An ampoule inspection machine is typically used in pharmaceutical manufacturing lines after the filling and sealing stages. The system verifies container integrity and detects visible particles before labeling and packaging, ensuring compliance with pharmaceutical quality standards.<\/p>\n<p>.<\/p>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                            \n                            <div class=\"tab__single\">\n                                <input type=\"checkbox\" id=\"chck3\">\n                                <label class=\"tab__singleTitle\" for=\"chck3\"><h3>What types of defects can your ampoues inspection systems identify?<\/h3><\/label>\n                                <div class=\"tab__singleContent\">\n                                    <div class=\"tab__singleContentInt\">\n                                        <ul>\n<li><strong>Contaminants:<\/strong>\u00a0Foreign particles inside the liquid.<\/li>\n<li><strong>Container Integrity:<\/strong>\u00a0Cracks, chips, or glass defects.<\/li>\n<li><strong>Fill Level:<\/strong>\u00a0Accurate verification of product volume.<\/li>\n<li><strong>Closure Inspection:<\/strong>\u00a0Inspection of the aluminum crimp, stopper, and proper sealing.<\/li>\n<li><strong>Cosmetics:<\/strong>\u00a0Scratchs, cracks cosmetic problems<\/li>\n<\/ul>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                            \n                            <div class=\"tab__single\">\n                                <input type=\"checkbox\" id=\"chck4\">\n                                <label class=\"tab__singleTitle\" for=\"chck4\"><h3>What types of defects can automatic visual inspection detect?<\/h3><\/label>\n                                <div class=\"tab__singleContent\">\n                                    <div class=\"tab__singleContentInt\">\n                                        <ul>\n<li>particulate contamination (glass, rubber, fibers)<\/li>\n<li>container defects (cracks, chips, scratches)<\/li>\n<li>fill-level variations (\u00b12-5% tolerance)<\/li>\n<li>closure issues (missing\/tilted plungers, tip caps)<\/li>\n<li>cosmetic defects (bubbles, discoloration, haze)<\/li>\n<li>label errors (missing, incorrect, misaligned)<\/li>\n<\/ul>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                            \n                            <div class=\"tab__single\">\n                                <input type=\"checkbox\" id=\"chck5\">\n                                <label class=\"tab__singleTitle\" for=\"chck5\"><h3>Which technologies are used to guarantee 100% inspection of production?<\/h3><\/label>\n                                <div class=\"tab__singleContent\">\n                                    <div class=\"tab__singleContentInt\">\n                                        <ul>\n<li><strong>Computer Vision:<\/strong>\u00a0High-resolution cameras for aesthetic and particulate inspection.<\/li>\n<li><strong>CCIT (Container Closure Integrity Testing):<\/strong>\u00a0Various technologies (such as High Voltage Leak Detection or vacuum decay) to check for microscopic leaks.<\/li>\n<li><strong><strong>Headspace Gas Analysis: t<\/strong><\/strong>o monitor gas composition inside the ampoules (essential for lyophilized or oxygen-sensitive products).<\/li>\n<li><strong>AI (Artificial Intelligence):<\/strong>\u00a0Advanced algorithms to reduce \u201cfalse rejects\u201d and improve detection in complex or dense products.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                            \n                            <div class=\"tab__single\">\n                                <input type=\"checkbox\" id=\"chck6\">\n                                <label class=\"tab__singleTitle\" for=\"chck6\"><h3>What speeds can your vial visual inspection machine achieve?<\/h3><\/label>\n                                <div class=\"tab__singleContent\">\n                                    <div class=\"tab__singleContentInt\">\n                                        <p>The VRI VI solution is designed for high-speed, high-performance inspection of ampoules, handling up to 400 pieces per minute. This advanced system integrates Automatic Visual Inspection (AVI) with Container Closure Integrity Testing (CCIT) using high-voltage technology. It can inspect the entire surface of each ampoules, ensuring comprehensive quality control. We offer solutions for every scale, from flexible units at up to 200 ppm to high-speed ampoules inspection systems reaching up to 400 ppm.<\/p>\n                                    <\/div>\n                                <\/div>\n                            <\/div>\n                                                <\/div>\n                <\/div>\n\n            <\/div>\n        <\/div>\n    <\/div>\n\n<\/div>\n\n<style>\n    .page-template-page_product .kfaq{margin-bottom: 0;}\n    .kfaq{background-color: #fbfbfb; border-radius: 0; padding-top: 80px; padding-bottom: 80px; margin-bottom: 100px;}\n    .kfaq img{border-radius: 30px; width: 100%; height: auto;}\n    .kfaq__colLeft{display: flex; align-items: center;}\n    .kfaq__colLeftCont h2{font-size: 40px; position: relative; padding-left: 30px; padding-top: 20px; padding-bottom: 20px;}\n    .kfaq__colLeftContDesc{width: 100%;}\n    .kfaq__colLeft a{color: #222222; font-weight: bold; margin-left: 30px;}\n\n    \/* new *\/\n    .kfaq__contTitle{display: flex; 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The system verifies container integrity and detects visible particles before labeling and packaging, ensuring compliance with pharmaceutical quality standards.<\\\/p>\\n<p>.<\\\/p>\\n\"                        }\n                    },                                {\n                        \"@type\": \"Question\",\n                        \"name\": \"What types of defects can your ampoues inspection systems identify?\",\n                        \"acceptedAnswer\": {\n                            \"@type\": \"Answer\",\n                            \"text\": \"<ul>\\n<li><strong>Contaminants:<\\\/strong>\u00a0Foreign particles inside the liquid.<\\\/li>\\n<li><strong>Container Integrity:<\\\/strong>\u00a0Cracks, chips, or glass defects.<\\\/li>\\n<li><strong>Fill Level:<\\\/strong>\u00a0Accurate verification of product volume.<\\\/li>\\n<li><strong>Closure Inspection:<\\\/strong>\u00a0Inspection of the aluminum crimp, stopper, and proper sealing.<\\\/li>\\n<li><strong>Cosmetics:<\\\/strong>\u00a0Scratchs, cracks cosmetic problems<\\\/li>\\n<\\\/ul>\\n\"                        }\n                    },                                {\n                        \"@type\": \"Question\",\n                        \"name\": \"What types of defects can automatic visual inspection detect?\",\n                        \"acceptedAnswer\": {\n                            \"@type\": \"Answer\",\n                            \"text\": \"<ul>\\n<li>particulate contamination (glass, rubber, fibers)<\\\/li>\\n<li>container defects (cracks, chips, scratches)<\\\/li>\\n<li>fill-level variations (\u00b12-5% tolerance)<\\\/li>\\n<li>closure issues (missing\\\/tilted plungers, tip caps)<\\\/li>\\n<li>cosmetic defects (bubbles, discoloration, haze)<\\\/li>\\n<li>label errors (missing, incorrect, misaligned)<\\\/li>\\n<\\\/ul>\\n\"                        }\n                    },                                {\n                        \"@type\": \"Question\",\n                        \"name\": \"Which technologies are used to guarantee 100% inspection of production?\",\n                        \"acceptedAnswer\": {\n                            \"@type\": \"Answer\",\n                            \"text\": \"<ul>\\n<li><strong>Computer Vision:<\\\/strong>\u00a0High-resolution cameras for aesthetic and particulate inspection.<\\\/li>\\n<li><strong>CCIT (Container Closure Integrity Testing):<\\\/strong>\u00a0Various technologies (such as High Voltage Leak Detection or vacuum decay) to check for microscopic leaks.<\\\/li>\\n<li><strong><strong>Headspace Gas Analysis: t<\\\/strong><\\\/strong>o monitor gas composition inside the ampoules (essential for lyophilized or oxygen-sensitive products).<\\\/li>\\n<li><strong>AI (Artificial Intelligence):<\\\/strong>\u00a0Advanced algorithms to reduce \u201cfalse rejects\u201d and improve detection in complex or dense products.<\\\/li>\\n<\\\/ul>\\n<p>&nbsp;<\\\/p>\\n<p>&nbsp;<\\\/p>\\n\"                        }\n                    },                                {\n                        \"@type\": \"Question\",\n                        \"name\": \"What speeds can your vial visual inspection machine achieve?\",\n                        \"acceptedAnswer\": {\n                            \"@type\": \"Answer\",\n                            \"text\": \"<p>The VRI VI solution is designed for high-speed, high-performance inspection of ampoules, handling up to 400 pieces per minute. 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